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Hepatic impairment: Get started conservatively using a reduced than typical dose; titrate very carefully to ideal outcome.CYP450 3A4 Conversation: The concomitant use with CYP450 3A4 inhibitors (or discontinuation of CYP450 3A4 inducers) may well end in a fatal overdose of oxycodone.Administer just one-half of the total day-to-day oxycodone hydroch